![]() ![]() ![]() Mice appeared healthy by daily video health checks and body, adrenal, and spleen weights of 37d-flight (FLT) mice did not differ from ground controls housed in flight hardware (GC), while thymus weights were 35% greater in FLT than GC. Mice were euthanized on-orbit, livers and spleens dissected, and remaining tissues frozen in situ for later analyses. For NASA’s Rodent Research-1 mission, female mice (ten 32 wk C57BL/6NTac ten 16 wk C57BL/6J) were launched on an unmanned vehicle, then resided on the International Space Station for 21/22d or 37d in microgravity. Capabilities were developed to perform experiments in low earth orbit with on-board sample recovery, thereby avoiding complications caused by return to Earth. ![]() Animal models are useful for exploring the health consequences of prolonged spaceflight. ![]()
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